OpenAI readies GPT-5 for August debut

PLUS: AI designs cancer-killing proteins in weeks

AuthorAuthor

Zach Mink & Rowan Cheung
July 25, 2025

Good morning, AI enthusiasts. GPT-5 is reportedly coming in August, and OpenAI CEO Sam Altman calls using the model a “here it is moment.”

As the company prepares to drop both its new flagship system and its first open-weight model in years, the next month could bring a new seismic shift in AI’s capabilities — if they can live up to the massive expectations.

Reminder: Our next live workshop is today at 4 PM EST — join and learn how to build useful AI agents with ChatGPT and become familiar with the broader ecosystem of agentic tools. RSVP here.

In today’s AI rundown:

  • OpenAI readies GPT-5 for August debut

  • AI designs cancer-killing proteins in weeks

  • Turn Comet into an AI-powered productivity assistant

  • Microsoft maps how workers use AI

  • 4 new AI tools & 4 job opportunities

LATEST DEVELOPMENTS

OPENAI

Image source: Theo Von on YouTube

The Rundown: OpenAI is reportedly planning to launch its next-gen GPT-5 in August, according to a report from The Verge — with CEO Sam Altman also speaking about the new model this week in a conversation with comedian Theo Von.

The details:

  • GPT-5 will combine language capabilities with o3-style reasoning into one system, eliminating the need to choose between models for various tasks.

  • Sam Altman described testing GPT-5 as a "here it is moment," claiming it instantly solved questions that made him feel "useless relative to the AI."

  • Altman said GPT-5 will be released “soon” but noted it will not have the capabilities used to achieve the recent gold medal at the IMO competition.

  • OAI also reportedly plans to release its first open-weight model since 2019 by the end of July, following a delay in its initial launch date due to safety tests.

Why it matters: Both GPT-5 and the open-weight model come with months of hype and extremely high expectations, but this next generation of models feels like a true step into the unknown. With Altman and others openly talking about existential shifts and mind-blowing capabilities, August could be the next major raising of the AI bar.

TOGETHER WITH SAMBANOVA

The Rundown: SambaNova’s cloud platform lets you build with the best open-source models from Llama, DeepSeek, OpenAI, and more. All models are optimized with lightning-fast inference speed and powered by SambaNova’s purpose-built AI chip, the SN40L Reconfigurable Dataflow Unit (RDU).

SambaCloud offers:

  • Integrations to the most popular frameworks and tools such as Hugging Face, CrewAI, and Cline

  • APIs for building and a playground to test things out.

  • Availability through the AWS Marketplace

AI & CANCER RESEARCH

Image source: Science 2025

The Rundown: Scientists from the Technical University of Denmark just developed an AI platform that designs custom proteins in weeks rather than years, enabling immune (T) cells to target and destroy cancer cells.

The details:

  • The system leverages three AI models to design "minibinder" proteins that attach to T cells, giving them “molecular GPS” to locate cancers like melanoma.

  • Researchers used the platform to design proteins for both common and patient-specific cancer markers, showing potential for tailored treatments.

  • The platform also includes virtual safety screening to predict and eliminate designs that might attack healthy cells before any lab testing begins.

  • It uses Google’s Nobel Prize-winning AlphaFold2 to predict proteins, with designs and testing happening in weeks versus years with other methods.

Why it matters: Another day, another AI medical breakthrough — and the sheer testing time compression these systems enable is leading to a flood of new discoveries. It also shows the potential of a “personalized medicine” future, with AI eventually being able to quickly design treatments tailored to the needs of each patient.

AI TRAINING

The Rundown: In this tutorial, you will learn how to use Perplexity’s Comet AI browser to connect to your calendar and email and get intelligent summaries, event management, and automated company research based on your meetings.

Step-by-step:

  1. In Perplexity Comet, select your profile, Connectors, and enable Calendar and Email

  2. Get quick overviews: “What's on my calendar next week?”

  3. Reschedule with communication: “Move my tennis event to Friday, 25th, same time, and draft an email to the participant asking if that works”

  4. Research and prep questions: “I have two calls on Wed, can you give me the latest AI news about those two companies and prepare me 3 questions to ask”

Pro tip: Use the research and question prep feature before every business meeting to lead more productive conversations.

PRESENTED BY FIDDLER

The Rundown: Fiddler’s 2025 Enterprise Guardrails Benchmarks Report delivers objective data comparisons to navigate tradeoffs and help you choose the right guardrails for any LLM use case.

In the report, you’ll learn:

  • Detailed breakdowns of offerings from OpenAI, Amazon Bedrock, Azure, and Fiddler AI

  • Value metrics covering latency, cost, and accuracy for every application size

  • Security performance across jailbreak resistance, toxicity control, and faithfulness

AI RESEARCH

Image source: Midjourney

The Rundown: Microsoft just analyzed 200,000 conversations with Bing Copilot to reveal the jobs and tasks people are currently delegating to AI, investigating which occupations will be most and least impacted by the rapidly transforming workforce.

The details:

  • The most common user requests involved gathering info and writing content, with AI most frequently acting as a teacher, advisor, or info provider to users.

  • An “AI applicability score” linked AI usage to occupations, with data showing the highest impact for computer science, office support, sales, and media roles.

  • Jobs with low impact scores included those with hands-on tasks like phlebotomists, nursing assistants, maintenance workers, and surgeons.

  • Researchers found a weak correlation between wages and AI exposure, which goes against predictions that high earners would be disrupted by the tech.

Why it matters: This data shows a practical link between what AI excels at and where those skills translate directly to in the job market, and many of the highest exposures are already facing those massive disruptions. Plus — despite the huge advances with robotics, it appears physical and hands-on jobs are still the safest bet (for now).

QUICK HITS

  • 🤖 Moby Agents - Triple Whale’s AI agent suite for e-commerce

  • ⚡️ GitHub Spark - Create full-stack apps with natural language prompts

  • 🧠 Ash - AI mental health app for anxiety, stress, and growth

  • 💎 Opal - Build and share AI mini-apps with natural language

  • 💵 Glean - Accounts Payable Analyst

  • 🤝 UiPath - Enterprise Account Executive

  • 📈 Meta - Growth Marketing Manager, B2B AI

  • 🔧 Perplexity AI - Quality Engineer, Comet

Elon Musk posted that X is planning to revive Vine, “but in AI form” — with the beloved video app’s IP currently owned by Twitter (now X).

Similarweb published an update to its AI platform data, with OpenAI’s ChatGPT still accounting for 78% of total traffic share and Google in second at 8.7%.

HiDream released HiDream-E1.1, a new updated image editing model that climbs to the top spot in Artificial Analysis’ Image Editing Arena amongst open-weight models.

Alibaba released Qwen3-MT, an AI translation model with support for 92+ languages and strong performance across benchmarks.

Figma announced the general availability of Figma Make, a prompt-to-code tool that allows users to transform designs into interactive prototypes.

Google introduced Opal, a new Labs experiment that converts natural language prompts into editable, shareable AI mini apps with customizable workflows.

COMMUNITY

Join our next workshop today at 4 PM EST with Dr. Alvaro Cintas, The Rundown’s AI professor. By the end of the workshop, you’ll know how to build useful AI agents with ChatGPT and understand the broader ecosystem of agentic tools out there.

RSVP here. Not a member? Join The Rundown University on a 14-day free trial.

That's it for today!

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See you soon,

Rowan, Joey, Zach, Alvaro, and Jason—The Rundown’s editorial team

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